Suppose you were a deciding member in a new company that was considering whether to use a bacterial plasmid..?

In theory, the use of gene therapy would restore the expression of a gene to a cell that lacks the expression of a particular protein. To achieve this, the DNA encoding the protein must be delivered to the and stably maintained within the cell. Suppose you were a deciding member in a new company that was considering whether to use a bacterial plasmid in upcoming human gene therapy trials. Would you support this decision? What considerations should be made with respect to DNA replication and transcription?